독성유전체 지식베이스 구축

우정훈1), 김민구1), 박유랑1), 이혜원1), 김주한*1)

1)서울대학교 의과대학 생명정보학 연구실

Abstract : Toxicogenomics combines transcript, protein and metabolite profiling with conventional toxicology to investigate the interaction between genes and environmental stress in disease caution. Toxicogenomics faces the problems of data comparison and data integration across different sources of data. There are already existing databases which claim to stand for toxicogenomics database. However, these databases just contain limited information of toxicogenomics. For integration of conventional toxicological data and new '-omics' technological data, now we propose novel toxicogenomics knowledgebase system, XPERANTO-TOX. XPERANTO-TOX is composed of three different closely connected system. Firstly, Data Repository System is for storing microarray data and histopathological data. Secondly, Data Annotation System is for giving higher level insight of data to researcher. At last, Data Analysis System consists of analytical modules for integrated toxicogenomics data.
keyword : Toxicogenomics, data integration, microarray data, histopathological data, data annotation, data analysis

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